Funded by NIH, the University of Pittsburgh Low Back Pain: Biological, Biomechanical, Behavioral Phenotypes (LB3P) Mechanistic Research Center aims to comprehensively phenotype chronic low back pain (CLBP) patients using a multi-modal approach. By identifying distinct CLBP phenotypes, targeted treatments can be developed, addressing rising costs and opioid reliance. The center integrates research cores for data collection and analysis, support cores for data management, and a research project for deep phenotyping and treatment response assessment. Leveraging advanced analytics and a biopsychosocial approach, it seeks to transform CLBP care through personalized, patient-centric models, facilitated by interdisciplinary collaboration and efficient translation within the University of Pittsburgh’s robust academic medical environment. The LB3P: Low Back Pain Research Study is a Mechanistic Research Center funded through a U19 award from the National Institutes of Health’s HEAL (Helping to End Addiction Long-Term) Initiative, a strategic effort to combat the opioid epidemic in the United States. The Principal Investigators on the study are PM&R’s Dr. Gwen Sowa and Dr. Nam Vo (Dept. of Orthopaedic Surgery). Dr. Bell serves as the co-director of the Biomechanical Core along with Dr. William Anderst, which oversees the collection and analyses of a comprehensive set of biomechanical (of varying degrees of sensitivity). Dr. Bell has also received ancillary funding from the BACPAC Consortium to participate in the BEST Trial, collect data on non-LBP controls, compare the biomechanical technologies withing the BACPAC consortium, and a diversity supplement to fund a graduate student researcher.